Publications

Current Publications

  • Soto JS, Neupane C, Kaur M, Pandey V, Wohlschlegel JA & BS Khakh (2024) Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice. Neuron 112: 3412-23.
  • Ollivier M, Soto JS, Linker KE, Moye SL, Jami-Alahmadi Y, Jones AE, Divakaruni AS, Kawaguchi R, Wohlschlegel JA & Khakh BS Crym-positive striatal astrocytes gate perseverative behaviour. Nature (Article) 627(8003):358-366.
  • Baldwin KT, Murai KK, Khakh BS (2024) Astrocyte morphology. Trends Cell Biol 34(7):547-565.
     
  • Soto JS, Jami-Alahmadi Y, Wohlschlegel JA & Khakh BS (2024) In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation. Nature Protocols 2024 19:896-927.
  • JS. Soto, Y. Jami-Alahmadi, J. Chacon, SL. Moye, B. Diaz-Castro, JA. Wohlschlegel & BS. Khakh (2023) Astrocyte and neuron subproteomes and obsessive-compulsive disorder mechanisms. Nature, 616: 764-773. Open access.
  • BS. Khakh & S. Goldman. Astrocytic contributions to Huntington’s disease pathophysiology (2023). Ann NY Acad Sci. doi:10.1111/nyas.14977. PMCID: pending.
  • MR, Gangwani, J, Soto, Y, Jami-Alahmadi, S, Tiwari, R, Kawaguchi, JA, Wohlschlegel, & BS Khakh (2023). Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors. Cell Reports 42, 111953 January 31 2023. PMCID: 36640336.
  • Endo F, Kasai A, Soto JS, Yu X, Qu Z, Hashimoto H, Gradinaru V, Kawaguchi R, & Khakh BS (2022). Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science (Research Article) Nov 4;378(6619):eadc9020. doi: 10.1126/science.adc9020.
  • Diaz-Castro B, Bernstein AM, Coppola G, Sofroniew MV. & Khakh BS (2021). Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation. Cell Reports 36: 109508.
  • Nagai J, Bellafard A, Qu Z, Yu X, Ollivier M, Gangwani MR, Diaz-Castro B, Coppola G, Schumacher SM, Golshani P, Gradinaru V, Khakh BS (2021). Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK. Neuron 109: 2256-2274.
  • Yu X, Moye SL, Khakh BS (2021). Local and CNS-Wide Astrocyte Intracellular Calcium Signaling Attenuation In Vivo with CalExflox Mice. Journal of Neuroscience 41: 4556-4574.
  • Kronschläger MT, Siegert ASM, Resch FJ, Rajendran PS, Khakh BS, Sandkühler J (2021). Lamina-specific properties of spinal astrocytes. Glia 69:1749-1766.
  • Nagai J, Yu X, Papouin T, Cheong E, Freeman MR, Monk KR, Hastings MH, Haydon PG, Rowitch D, Shaham S. & Khakh BS (2021) Behaviorally consequential astrocytic regulation of neural circuits. Neuron, 109; 576-595.
  • Yu X, Nagai J, Marti-Solano M, Soto J.S, Coppola G, Babu M.M, Khakh B.S. (2020) Context-specific striatal astrocyte molecular responses are phenotypically exploitable. Neuron. Oct 9:S0896-6273(20)30745-5. doi: 10.1016/j.neuron.2020.09.021.
  • Yu, X. Nagai, J. & Khakh, B.S. (2020) Improved tools to study astrocytes. Nature Reviews Neuroscience, 21; 121-38


 

  • Diaz-Castro, B. Gangwani, M. Yu, X. Coppola, G. & Khakh, B.S. (2019) Astrocyte molecular signatures in Huntington's disease. Science Translational Medicine (Article), Oct 16;11(514). pii: eaaw8546.
  • Khakh, B.S. & Deneen, B. (2019) The emerging nature of astrocyte diversity. Annual Review of Neuroscience, 42; 187-207
  • Octeau, J.C. Gangwani, M. Allam, S.L. Tran, D. Huang, S. Hoang Trong, T.M. Golshani, P. Rumbell, T.H. Kozloski, J.R. & Khakh, B.S. (2019) Transient, consequential increases in extracellular potassium ions accompany Channelrhodopsin2 (ChR2) excitation. Cell Reports, 27; 2249-61.
  • Nagai, J. Rajbhandari, AK. Gangwani, MR. Hachisuka, A. Coppola, G. Masmanidis, SC. Fanselow, MS. & Khakh BS (2019) Hyperactivity with disrupted attention by activation of an astrocyte synaptogenic cue. Cell, 177; 1280-92.
  • Lobas M, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL & Khakh BS (2019) A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP. Nature Communications, 10, Article number: 711 (2019)
  • Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G & Khakh BS (2018) Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior. Neuron, 99: 1170-87.
  • Octeau JC, Chai HC, Jiang R, Bonanno SL, Martin KC & Khakh BS (2018) An optical neuron-astrocyte proximity assay at synaptic distance scales. Neuron, 98: 49-66.
  • *Chai H, *Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G & Khakh BS (2017) Neural circuit-specialized astrocytes: transcriptomic, proteomic, morphological and functional evidence. Neuron, 95: 531-549. *Co-first authors
  • Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R (2017) Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease. Trends Neurosci, 40: 422-437.
  • *Srinivasan R, *Lu T-Y, *Chai H, Xu J, Huang BS, Golshani P, Coppola G & Khakh BS (2016) New transgenic mouse lines for selectively targeting astrocytes and for studying calcium signals in astrocyte processes in situ and in vivo. Neuron, 92: 1181-1195. *Co-first authors
  • Xu J, Bernstein A, Wong A, Lu X, Khoja S, Yang XW, Davies D, Micevych P, Sofroniew MV & Khakh BS (2016) P2X4 receptor reporter mice: sparse brain expression and feeding-related presynaptic facilitation in the arcuate nucleus. Journal of Neuroscience; 36: 8902-20
  • Jiang R, Diaz-Castro B, Looger LL & Khakh BS. (2016) Dysfunctional calcium and glutamate signaling in striatal astrocytes from Huntington's disease model mice. Journal of Neuroscience; 36: 3453-70
  • Shigetomi E, Patel S & Khakh BS (2016) Probing the complexities of astrocyte calcium signaling. Trends Cell Biology 26: 300-12
  • Khakh BS & Sofroniew MV (2015) Diversity of astrocyte functions and phenotypes in neural circuits. Nature Neuroscience 18, 942-52
  • Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P & Khakh BS. (2015) Ca2+ signaling in astrocytes from Ip3r2-/- mice in brain slices and during startle responses in vivo. Nature Neuroscience, Nature Neuroscience 18, 708-17
  • Xu J, Chai H, Ehinger K, Egan TM, Srinivasan R, Frick M & Khakh BS. (2014) Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. J Gen Physiol, 2014 Jun 16. pii: jgp.201411169. [Epub ahead of print]
  • Haustein MD, Kracun S, Lu XH, Shih T, Jackson-Weaver O, Tong X, Xu J, Yang XW, O'Dell TJ, Marvin JS, Ellisman MH, Bushong EA, Looger LL & Khakh BS. Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. Neuron, 2014 Apr 16;82(2):413-29
  • Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV & Khakh BS. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat Neurosci., 2014 May;17(5):694-703


 

  • Shigetomi E, Jackson-Weaver O, Huckstepp RT, O'Dell TJ, & Khakh BS. TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. J Neurosci., 2013 Jun 12;33(24):10143-53
  • Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH & Khakh BS. Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J Gen Physiol., 2013 May;141(5):633-47
  • Richler E, Chaumont S, Shigetomi E, Sagasti A & Khakh BS. Tracking transmitter-gated P2X cation channel activation in vitro and in vivo. Nat Methods, 2008 Jan;5(1):87-93

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